Recombinant Human IL-31 0 ReviewsSubmit a Review Product Details Catalogue Number: 200-31 Description: Human IL-31 is a T cell-derived cytokine that shares several structural and functional characteristics with IL-6, Oncostatin M, LIF, and Cardiotrophin-1. It signals through a receptor complex comprised of GPL (also known as gp130-like receptor or IL-31RA) and Oncostatin-M receptor (OSMR). GPL/OSMR signaling is a strong activator of STAT3 and STAT5, and can also activate STAT1, JAK1, and JAK2 signaling pathways. IL-31-regulated immune responses have been implicated in skin physiology and inflammatory skin diseases. Recombinant Human IL-31 is a 15.8 kDa protein containing 141 amino acid residues. Source: E.coli Synonyms: Interleukin-31 AA Sequence: SHTLPVRLLR PSDDVQKIVE ELQSLSKMLL KDVEEEKGVL VSQNYTLPCL SPDAQPPNNI HSPAIRAYLK TIRQLDNKSV IDEIIEHLDK LIFQDAPETN ISVPTDTHEC KRFILTISQQ FSECMDLALK SLTSGAQQAT T Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Measured by its ability to induce STAT3 activation in human U87 cells. Calculated Molecular Weight: 15.8 kDa Accession Number: Q6EBC2 Gene ID: 386653 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse, References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Immune System Inflammation Stem Cells & Differentiation product.subtitle.recentcitations First Author Braz, J M Title Genetic priming of sensory neurons in mice that overexpress PAR2 enhances allergen responsiveness. Citation Proceedings of the National Academy of Sciences of the United States of America; 118(8) PubMed Id 33602818 First Author Umehara, Y Title Robust induction of neural crest cells to derive peripheral sensory neurons from human induced pluripotent stem cells. Citation Scientific Reports; 10(1) pg4360 PubMed Id 32152328 First Author Raap, U Title Human basophils are a source of - and are differentially activated by - IL-31. Citation Clinical And Experimental Allergy : Journal Of The British Society For Allergy And Clinical Immunology; 47(4) pg499-508 PubMed Id 28000952
