Recombinant Human MCP-1 (CCL2) 0 ReviewsSubmit a Review Product Details Catalogue Number: 300-04 Description: The MCP proteins are members of the CC chemokine family that signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross-reacts across species. Recombinant Human MCP-1 is an 8.6 kDa protein containing 76 amino acid residues, including the four highly conserved cysteine residues present in the CC chemokines. Source: E.coli Synonyms: Monocyte Chemotactic Protein-1, CCL2, MCAF, JE (murine) AA Sequence: QPDAINAPVT CCYNFTNRKI SVQRLASYRR ITSSKCPKEA VIFKTIVAKE ICADPKQKWV QDSMDHLDKQ TQTPKT Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human monocytes using a concentration range of 10.0-100.0 ng/ml. Calculated Molecular Weight: 8.6 kDa Accession Number: P13500 Gene ID: 6347 crossreactivity: Bacteria, Chicken, Hamster, Human, Human + Mouse, Human + Parasite, Human + Rat, Monkey, Mouse, Pig, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Angiogenesis/Cardiovascular Cancer Chemotaxis Immune System Inflammation Neurobiology Wound Healing Allergy product.subtitle.recentcitations First Author Bonecchi, R Title Up-regulation of CCR1 and CCR3 and induction of chemotaxis to CC chemokines by IFN-gamma in human neutrophils. Citation Journal of immunology (Baltimore, Md. : 1950); 162(1) pg474-9 PubMed Id 9886422 First Author Nardelli, B Title Characterization of the signal transduction pathway activated in human monocytes and dendritic cells by MPIF-1, a specific ligand for CC chemokine receptor 1. Citation Journal of immunology (Baltimore, Md. : 1950); 162(1) pg435-44 PubMed Id 9886417 First Author van den Berg, R H Title The first subcomponent of complement, C1q, triggers the production of IL-8, IL-6, and monocyte chemoattractant peptide-1 by human umbilical vein endothelial cells. Citation Journal of immunology (Baltimore, Md. : 1950); 161(12) pg6924-30 PubMed Id 9862726
