Recombinant Human MCP-1 (CCL2)

Product Details

Catalogue Number: 300-04

Description:

The MCP proteins are members of the CC chemokine family that signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross-reacts across species. Recombinant Human MCP-1 is an 8.6 kDa protein containing 76 amino acid residues, including the four highly conserved cysteine residues present in the CC chemokines.

Source: E.coli

Synonyms: Monocyte Chemotactic Protein-1, CCL2, MCAF, JE (murine)

AA Sequence: QPDAINAPVT CCYNFTNRKI SVQRLASYRR ITSSKCPKEA VIFKTIVAKE ICADPKQKWV QDSMDHLDKQ TQTPKT

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human monocytes using a concentration range of 10.0-100.0 ng/ml.

Calculated Molecular Weight: 8.6 kDa

Accession Number: P13500

Gene ID: 6347

Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug)

crossreactivity:

Bacteria, Chicken, Hamster, Human, Human + Mouse, Human + Parasite, Human + Rat, Monkey, Mouse, Pig, Rat

Country Of Origin: USA

Not for human use.

Research Interest

COVID-19

Angiogenesis/Cardiovascular

product.subtitle.recentcitations

First Author

Bluhmki, T

Title

Functional human iPSC-derived alveolar-like cells cultured in a miniaturized 96‑Transwell air-liquid interface model.

Citation

Scientific Reports; 11(1) pg17028

PubMed Id

34426605

First Author

Fang, W B

Title

Expression of CCL2/CCR2 signaling proteins in breast carcinoma cells is associated with invasive progression

Citation

Scientific Reports; 11(1) pg8708

PubMed Id

33888841

First Author

Ocaña-Guzmán, R

Title

Leukocytes from Patients with Drug-Sensitive and Multidrug-Resistant Tuberculosis Exhibit Distinctive Profiles of Chemokine Receptor Expression and Migration Capacity.

Citation

Journal Of Immunology Research; 2021 pg6654220

PubMed Id

33977111

Chemokines