Recombinant Human MCP-1 (CCL2)

Product Details

Catalogue Number: 300-04

Description:

The MCP proteins are members of the CC chemokine family that signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross-reacts across species. Recombinant Human MCP-1 is an 8.6 kDa protein containing 76 amino acid residues, including the four highly conserved cysteine residues present in the CC chemokines.

Source: E.coli

Synonyms: Monocyte Chemotactic Protein-1, CCL2, MCAF, JE (murine)

AA Sequence: QPDAINAPVT CCYNFTNRKI SVQRLASYRR ITSSKCPKEA VIFKTIVAKE ICADPKQKWV QDSMDHLDKQ TQTPKT

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human monocytes using a concentration range of 10.0-100.0 ng/ml.

Calculated Molecular Weight: 8.6 kDa

Accession Number: P13500

Gene ID: 6347

crossreactivity:

Bacteria, Chicken, Hamster, Human, Human + Mouse, Human + Parasite, Human + Rat, Monkey, Mouse, Pig, Rat

Country Of Origin: USA

Not for human use.

Research Interest

COVID-19

Angiogenesis/Cardiovascular

product.subtitle.recentcitations

First Author

Pontejo, S M

Title

Two glycosaminoglycan-binding domains of the mouse cytomegalovirus-encoded chemokine MCK-2 are critical for oligomerization of the full-length protein.

Citation

The Journal of Biological Chemistry; 292(23) pg9613-9626

PubMed Id

28432120

First Author

Chen, T

Title

Spinal microglial motility is independent of neuronal activity and plasticity in adult mice.

Citation

Molecular Pain; 6 pg19

PubMed Id

20380706

First Author

Zhang, Y

Title

A new antagonist for CCR4 attenuates allergic lung inflammation in a mouse model of asthma.

Citation

Scientific Reports; 7(1) pg15038

PubMed Id

29118379

Chemokines