Animal-Free Cytokines

Animal-Free Recombinant Human Artemin

Detalles del Producto

Nùmero de Catalogo AF-450-17
Descripcion

Artemin is a disulfide-linked homodimeric neurotrophic factor structurally related to GDNF, Artemin, Neurturin and Persephin. These proteins belong to the cysteine knot superfamily of growth factors that assume stable dimeric protein structures. Artemin, GDNF, Persephin and Neurturin all signal through a multicomponent receptor system, composed of RET (receptor tyrosine kinase) and one of the four GFRα (α1-α4) receptors. Artemin prefers the receptor GFRα3-RET, but will use other receptors as an alternative. Artemin supports the survival of all peripheral ganglia, such as sympathetic, neural crest and placodally-derived sensory neurons, and dopaminergic midbrain neurons. The functional human Artemin ligand is a disulfide-linked homodimer of two 12.0 kDa polypeptide monomers. Each monomer contains seven conserved cysteine residues, one of which is used for interchain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine-knot configuration.Recombinant Human Artemin is a 24.2 kDa, disulfide-linked homodimer formed by two identical 113 amino acid subunits.

Manufactured using all Animal-Free reagents.

Source: E.coli

Synonyms: ART, ARTN, Enovin, Neublastin

AA Sequence (monomer): AGGPGSRARA AGARGCRLRS QLVPVRALGL GHRSDELVRF RFCSGSCRRA RSPHDLSLAS LLGAGALRPP PGSRPVSQPC CRPTRYEAVS FMDVNSTWRT VDRLSATACG CLG

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Not available.

Calculated Molecular Weight: 24.2 kDa

Accession Number: Q5T4W7

Gene ID: 9048

Research Interest

Country Of Origin: USA

Not for human use.