Facteurs de Croissance et Cytokines

Recombinant Human IGF-BP2

Product Details

Catalogue Number: 350-06B
Description:

IGF-BPs control the distribution, function and activity of IGFs in various cell tissues and body fluids.  Currently, there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II.  IGF-BP2 is a cysteine-rich, secreted protein produced by bone cells, and is most abundant in the brain.  IGF-BP2 has been shown to inhibit IGF-II action in human breast and ovarian carcinoma cells.  Recombinant Human IGF-BP2 is a 31.5 kDa protein consisting of 289 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain.

Source: (BTI-Tn-5B1-4) Hi-5 Insect cells

Synonyms: Insulin-like Growth Factor-Binding Protein 2, IBP-2

AA Sequence: EVLFRCPPCT PERLAACGPP PVAPPAAVAA VAGGARMPCA ELVREPGCGC CSVCARLEGE ACQVYTPRCG QGLRCYPHPG SELPLQALVM GEGTCEKRRD AEYGASPEQV ADNGDDHSEG GLVENHVDST MNMLGGGGSA GRKPLKSGMK ELAVFREKVT EQHRQMGKGG KHHLGLEEPK KLRPPPARTP CQQELDQVLE RISTMRLPDE RGPLEHLYSL HIPNCDKHGL YNLKQCKMSL NGQRGECWCV NPNTGKLIQG APTIRGDPEC HLFYNEQQEA RGVHTQRMQ

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells.

Calculated Molecular Weight: 31.5 kDa

Accession Number: P18065

Gene ID: 3485

Note:

1mg will be provided as 2x500μg.

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Stephenson, S
Title
Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells.
Citation
Journal of immunology (Baltimore, Md. : 1950); 202(4) pg1287-1300
PubMed Id
First Author
Qin, E Y
Title
Neural Precursor-Derived Pleiotrophin Mediates Subventricular Zone Invasion by Glioma.
Citation
Cell; 170(5) pg845-859.e19
PubMed Id
First Author
Nixon, C C
Title
Cocaine exposure impairs multilineage hematopoiesis of human hematopoietic progenitor cells mediated by the sigma-1 receptor [corrected].
Citation
Scientific Reports; 5 pg8670
PubMed Id