Recombinant Human IGF-BP2 0 ComentariosSubmit a Review Detalles del Producto Nùmero de Catalogo 350-06B Descripcion IGF-BPs control the distribution, function and activity of IGFs in various cell tissues and body fluids. Currently, there are seven named IGF-BPs that form high affinity complexes with both IGF-I and IGF-II. IGF-BP2 is a cysteine-rich, secreted protein produced by bone cells, and is most abundant in the brain. IGF-BP2 has been shown to inhibit IGF-II action in human breast and ovarian carcinoma cells. Recombinant Human IGF-BP2 is a 31.5 kDa protein consisting of 289 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain. Source: (BTI-Tn-5B1-4) Hi-5 Insect cells Synonyms: Insulin-like Growth Factor-Binding Protein 2, IBP-2 AA Sequence: EVLFRCPPCT PERLAACGPP PVAPPAAVAA VAGGARMPCA ELVREPGCGC CSVCARLEGE ACQVYTPRCG QGLRCYPHPG SELPLQALVM GEGTCEKRRD AEYGASPEQV ADNGDDHSEG GLVENHVDST MNMLGGGGSA GRKPLKSGMK ELAVFREKVT EQHRQMGKGG KHHLGLEEPK KLRPPPARTP CQQELDQVLE RISTMRLPDE RGPLEHLYSL HIPNCDKHGL YNLKQCKMSL NGQRGECWCV NPNTGKLIQG APTIRGDPEC HLFYNEQQEA RGVHTQRMQ Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to inhibit IGF-I induced proliferation of FDC-P1 cells. Calculated Molecular Weight: 31.5 kDa Accession Number: P18065 Gene ID: 3485 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) Note: 1mg will be provided as 2x500μg. crossreactivity: Human, Mouse References PubMed SDS Búsqueda del CoA Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Apoptosis Cancer Diabetes/Weight Regulation product.subtitle.recentcitations Primer autor Stephenson, S Titulo Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells. Citar Journal of immunology (Baltimore, Md. : 1950); 202(4) pg1287-1300 PudMed id 30642980 Primer autor Qin, E Y Titulo Neural Precursor-Derived Pleiotrophin Mediates Subventricular Zone Invasion by Glioma. Citar Cell; 170(5) pg845-859.e19 PudMed id 28823557 Primer autor Nixon, C C Titulo Cocaine exposure impairs multilineage hematopoiesis of human hematopoietic progenitor cells mediated by the sigma-1 receptor [corrected]. Citar Scientific Reports; 5 pg8670 PudMed id 25728014