Facteurs de Croissance et Cytokines

Recombinant Human IL-1RA

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Product Details

Catalogue Number: 200-01RA
Description:
Recombinant Human IL-1RA

Interleukin-1 receptor antagonist (IL-1RA) is a naturally-occurring, inflammatory-inhibitor protein.  It inhibits the activity of IL-1α and IL-1β by competitively blocking their binding to type I and type II receptors.  IL-1RA is produced by corneal epithelial cells, monocytes, neutrophils, macrophages, and fibroblasts.  Therapeutically, IL-1RA may help in the treatment of sepsis, cachexia, rheumatoid arthritis, chronic myelogenous leukemia, asthma, psoriasis, and inflammatory bowel disease.  Recombinant Human IL-1RA is a 17.2 kDa protein consisting of 153 amino acid residues.

Source: E.coli

AA Sequence: MRPSGRKSSK MQAFRIWDVN QKTFYLRNNQ LVAGYLQGPN VNLEEKIDVV PIEPHALFLG IHGGKMCLSC VKSGDETRLQ LEAVNITDLS ENRKQDKRFA FIRSDSGPTT SFESAACPGW FLCTAMEADQ PVSLTNMPDE GVMVTKFYFQ EDE

Synonyms: IL-1Ra, ICIL-1RA, IRAP, IL-1RN

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to inhibit the IL-1α stimulation of murine D10S cell. The expected ED50 is 20-40 ng/ml in the presence of 50 pg/ml of IL-1α.

Calculated Molecular Weight: 17.2 kDa

Accession Number: P14778

Gene ID: 3554

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

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First Author
Bouhaddou, M
Title
The Global Phosphorylation Landscape of SARS-CoV-2 Infection.
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Cell; 182(3) pg685-712.e19
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Blanco-Melo, D
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Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19.
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Cell; 181(5) pg1036-1045.e9
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Iriondo, O
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TAK1 mediates microenvironment-triggered autocrine signals and promotes triple-negative breast cancer lung metastasis.
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Nature Communications; 9(1) pg1994
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