Recombinant Human Prokineticin-2 0 ReviewsSubmit a Review Product Details Catalogue Number: 100-46 Description: Prokineticin-2 (PK2) is a cysteine-rich secreted protein that is expressed in the testis and, in lower levels, in the small intestine. PK2 regulates various biological functions, including gastrointestinal motility, angiogenesis and circadian rhythms. It is closely related to EG-VEGF (Prokineticin-1), and binds to two orphan B-protein-coupled receptors termed PK-R1 and PK-R2. Recombinant Human Prokineticin-2 is an 8.8 kDa protein consisting of 81 amino acid residues, including ten cysteine residues that can potentially form five pairs of intra-molecular disulfide bonds. Source: E.coli Synonyms: PROK2, PK2, Protein Bv8 homolog AA Sequence: AVITGACDKD SQCGGGMCCA VSIWVKSIRI CTPMGKLGDS CHPLTRKVPF FGRRMHHTCP CLPGLACLRT SFNRFICLAQ K Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Not available. Calculated Molecular Weight: 8.8 kDa Accession Number: Q9HC23 Gene ID: 60675 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular product.subtitle.recentcitations First Author Noda, K Title Differential inflammation-mediated function of prokineticin 2 in the synovial fibroblasts of patients with rheumatoid arthritis compared with osteoarthritis Citation Scientific Reports; 11(1) pg18399 PubMed Id 34526577 First Author Qureshi, R Title A Prokineticin-Driven Epigenetic Switch Regulates Human Epicardial Cell Stemness and Fate. Citation Stem cells (Dayton, Ohio); 36(10) pg1589-1602 PubMed Id 29873146 First Author Xin, H Title G-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells. Citation The Journal of Biological Chemistry; 288(19) pg13842-9 PubMed Id 23548897
