Facteurs de Croissance et Cytokines

Recombinant Human GM-CSF

Product Details

Catalogue Number: 300-03
Description:
Recombinant Human GM-CSF

GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages, and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant Human GM-CSF is a 14.6 kDa globular protein consisting of 128 amino acids, containing two intramolecular disulfide bonds and two potential N-linked glycosylation sites.

Source: E.coli

Synonyms: Granulocyte-Macrophage Colony-Stimulating Factor, CSF-2, MGI-1GM, Pluripoietin-α

AA Sequence: MAPARSPSPS TQPWEHVNAI QEARRLLNLS RDTAAEMNET VEVISEMFDL QEPTCLQTRL ELYKQGLRGS LTKLKGPLTM MASHYKQHCP PTPETSCATQ IITFESFKEN LKDFLLVIPF DCWEPVQE

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.

This product has been tested against the WHO standard. International Unit information can be found here.

Recombinant Human GM-CSF Biological Activity Graph

Calculated Molecular Weight: 14.6 kDa

Accession Number: P04141

Gene ID: 1437

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Sabate-Soler, S
Title
Microglia integration into human midbrain organoids leads to increased neuronal maturation and functionality.
Citation
Glia; 70(7) pg1267-1288
PubMed Id
First Author
Miek, L
Title
Staphylococcus aureus controls eicosanoid and specialized pro-resolving mediator production via lipoteichoic acid.
Citation
Immunology; 166(1) pg47-67
PubMed Id
First Author
Zhang, S
Title
Nocardia rubra cell-wall skeleton influences the development of cervical carcinoma by promoting the antitumor effect of macrophages and dendritic cells.
Citation
Cancer Medicine; 11(5) pg1249-1268
PubMed Id

product.subtitle.productreviews

Existing reviews
Consistent
This product has been working pretty well for human primary myeloid cell assays with consistent results.
From:  Noriyuki | Date:  08/07/2020