Recombinant Human GM-CSF 1 ReviewsSubmit a Review Product Details Catalogue Number: 300-03 Description: GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages, and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant Human GM-CSF is a 14.6 kDa globular protein consisting of 128 amino acids, containing two intramolecular disulfide bonds and two potential N-linked glycosylation sites. Source: E.coli Synonyms: Granulocyte-Macrophage Colony-Stimulating Factor, CSF-2, MGI-1GM, Pluripoietin-α AA Sequence: MAPARSPSPS TQPWEHVNAI QEARRLLNLS RDTAAEMNET VEVISEMFDL QEPTCLQTRL ELYKQGLRGS LTKLKGPLTM MASHYKQHCP PTPETSCATQ IITFESFKEN LKDFLLVIPF DCWEPVQE Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 as determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 14.6 kDa Accession Number: P04141 Gene ID: 1437 crossreactivity: Bacteria, Chicken, Human, Human + Mouse, Leech, Mouse, Pig, Rabbit References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Cancer Cell Culture Immune System Inflammation Stem Cells & Differentiation Wound Healing product.subtitle.recentcitations First Author Zhou, Y Title Megakaryocytes participate in the occurrence of bleomycin-induced pulmonary fibrosis. Citation Cell Death & Disease; 10(9) pg648 PubMed Id 31501415 First Author Naqvi, A R Title miR-24, miR-30b and miR-142-3p interfere with antigen processing and presentation by primary macrophages and dendritic cells. Citation Scientific Reports; 6 pg32925 PubMed Id 27611009 First Author Hara-Chikuma, M Title Inhibition of aquaporin-3 in macrophages by a monoclonal antibody as potential therapy for liver injury Citation Nature Communications; 11(1) pg5666 PubMed Id 33168815 product.subtitle.productreviews Existing reviews Consistent This product has been working pretty well for human primary myeloid cell assays with consistent results. From: Noriyuki | Date: 08/07/2020 × Consistent This product has been working pretty well for human primary myeloid cell assays with consistent results. From: Noriyuki | Date: 08/07/2020 Close
