Recombinant Human TSLP 0 ReviewsSubmit a Review Product Details Catalogue Number: 300-62 Description: TSLP is a hemopoietic protein that is expressed in the heart, liver and prostate. TSLP overlaps biological activities with IL-7, and binds with the heterodimeric receptor complex consisting of the IL-7R α-chain (IL-7Rα) and the TSLP-specific chain (TSLPR). Like IL-7, TSLP induces phosphorylation of STAT3 and STAT5, but uses kinases other than the JAKs for activation. TSLP prohibits apoptosis and stimulates growth of the human acute myeloid leukemia (AML)-derived cell line MUTZ3. It induces the release of T cell-attracting chemokines TARC and MDC from monocytes, and activates CD11c(+) dendritic cells (DCs). TSLP-activated DCs have been shown to prime naïve T cells to produce the proallergic cytokines (IL-4, IL-5, IL-13, TNF-α) while down-regulating IL-10 and IFN-γ, suggesting a role in initiating allergic inflammation. Recombinant Human TSLP is a 15.0 kDa protein consisting of 132 amino acid residues. Source: E.coli Synonyms: Thymic Stromal Lymphopoietin AA Sequence: MYDFTNCDFE KIKAAYLSTI SKDLITYMSG TKSTEFNNTV SCSNRPHCLT EIQSLTFNPTAGCASLAKEM FAMKTKAALA IWCPGYSETQ INATQAMKKR RKRKVTTNKC LEQVSQLQGLWRRFNRPLLK QQ Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Not available. Calculated Molecular Weight: 15 kDa Accession Number: Q969D9 Gene ID: 85480 crossreactivity: Human, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Apoptosis Immune System Inflammation product.subtitle.recentcitations First Author Arnold, I C Title The GM-CSF-IRF5 signaling axis in eosinophils promotes antitumor immunity through activation of type 1 T cell responses. Citation The Journal of Experimental Medicine; 217(12) PubMed Id 32970801 First Author Tong, K I Title Attenuated DNA damage repair delays therapy-related myeloid neoplasms in a mouse model. Citation Cell death & disease; 7(10) pge2401 PubMed Id 27711078 First Author Guo, P Title Thymic stromal lymphopoietin from trophoblasts induces dendritic cell-mediated regulatory TH2 bias in the decidua during early gestation in humans. Citation Blood; 116(12) pg2061-9 PubMed Id 20538796