Recombinant Human/Murine/Rat BDNF 3 Avissubmitareview Détails du Produit Catalog Number: 450-02 Description: BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residues and a propeptide of 110 amino acid residues. Recombinant Human/Murine/Rat BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions. Source: E.coli Synonyms: Brain Derived Neurotrophic Factor, Abrineurin AA Sequence (monomer): MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 0.5-1.0 μg/ml. Calculated Molecular Weight: 27 kDa Accession Number: P23560 Gene ID: 627 crossreactivity: Chicken, Frog, Guinea Pig, Hamster, Human, Human + Mouse, Human + Rat, Human + Virus, Monkey, Mouse, Rat, Tadpole, tests Country Of Origin: USA Not for human use. References PubMed SDS Recherche de CoA Product Line Research Interest Organoids Neurobiology Stem Cells & Differentiation product.subtitle.productreviews Avis existants I have used PeproTech BDNF since 2012 I have used PeproTech BDNF at Stanford and Genentech since 2012 and it has been great for differentiating stem cells into neurons. It is the best product in this category of recombinant proteins. De: Louise | Date: 21/08/2020 × I have used PeproTech BDNF since 2012 I have used PeproTech BDNF at Stanford and Genentech since 2012 and it has been great for differentiating stem cells into neurons. It is the best product in this category of recombinant proteins. De: Louise | Date: 21/08/2020 Close Supports Growth of Cholinergic Neurons Routinely use this to support and maintain primary murine cholinergic neurons in culture. Excellent product. De: Bernadeta | Date: 26/08/2020 × Supports Growth of Cholinergic Neurons Routinely use this to support and maintain primary murine cholinergic neurons in culture. Excellent product. De: Bernadeta | Date: 26/08/2020 Close Differentiation and support of SH-SY5Y cells I have been using this product for over 3 years now to support and differentiate SH-SY5Y cells in culture. It is an excellent product that many people in my lab use. It always works well and is reliable. De: Crystal | Date: 29/08/2020 × Differentiation and support of SH-SY5Y cells I have been using this product for over 3 years now to support and differentiate SH-SY5Y cells in culture. It is an excellent product that many people in my lab use. It always works well and is reliable. De: Crystal | Date: 29/08/2020 Close
