Recombinant Human/Murine/Rat BDNF 0 Avissubmitareview Détails du Produit Catalog Number: 450-02 Description: BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residues and a propeptide of 110 amino acid residues. Recombinant Human/Murine/Rat BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions. Source: E.coli Synonyms: Brain Derived Neurotrophic Factor, Abrineurin AA Sequence (monomer): MHSDPARRGE LSVCDSISEW VTAADKKTAV DMSGGTVTVL EKVPVSKGQL KQYFYETKCN PMGYTKEGCR GIDKRHWNSQ CRTTQSYVRA LTMDSKKRIG WRFIRIDTSC VCTLTIKRGR Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 0.5-1.0 μg/ml. Calculated Molecular Weight: 27 kDa Accession Number: P23560 Gene ID: 627 crossreactivity: Chicken, Frog, Guinea Pig, Hamster, Human, Human + Mouse, Human + Rat, Human + Virus, Monkey, Mouse, Rat, Tadpole, tests Research Interest Organoids Neurobiology Stem Cells & Differentiation References PubMed SDS Product Line Country Of Origin: USA Not for human use.
