Neurotrophines

Recombinant Human NT-3

Product Details

Catalogue Number: 450-03
Description:


Recombinant Human NT-3

NT-3 is a neurotrophic factor structurally related to β-NGF, BDNF, and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. NT-3 is expressed by neurons of the central nervous system, and can signal through the trk receptors. NT-3 promotes the growth and survival of nerve and glial cells. The amino acid sequences of human, murine and rat NT-3 are identical. Recombinant Human NT-3 is a noncovalently linked homodimer of two 13.6 kDa polypeptide monomers (240 total amino acid residues).

Source: E.coli

Synonyms: Neurotrophin-3, Neurotrophic factor, Nerve Growth Factor-2 (NGF-2), HGNF

AA Sequence (monomer): MYAEHKSHRG EYSVCDSESL WVTDKSSAID IRGHQVTVLG EIKTGNSPVK QYFYETRCKE ARPVKNGCRG IDDKHWNSQC KTSQTYVRAL TSENNKLVGW RWIRIDTSCV CALSRKIGRT

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to bind recombinant human TrkB Fc Chimera in a functional ELISA.

Calculated Molecular Weight: 27.2 kDa

Accession Number: P20783

Gene ID: 4908

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Truvé, K
Title
Identification of candidate genetic variants and altered protein expression in neural stem and mature neural cells support altered microtubule function to be an essential component in bipolar disorder
Citation
Translational Psychiatry; 10(1) pg390
PubMed Id
First Author
Bayó-Puxan, N
Title
Lysosomal and network alterations in human mucopolysaccharidosis type VII iPSC-derived neurons.
Citation
Scientific Reports; 8(1) pg16644
PubMed Id
First Author
Nzou, G
Title
Human Cortex Spheroid with a Functional Blood Brain Barrier for High-Throughput Neurotoxicity Screening and Disease Modeling.
Citation
Scientific Reports; 8(1) pg7413
PubMed Id

product.subtitle.productreviews

Existing reviews
I have used PeproTech NT-3 since 2012
Like my usage of BDNF since 2012 at Stanford and Genentech, I have also used Peprotech NT-3 and it is the best recombinant product. I highly recommend these reagents for neuronal differentiation!
From:  Louise | Date:  21/08/2020
Recombinant Human NT-3
This product works great for neural differentiation and consistently works. Products are always delivered on time and good quality.
From:  Aala | Date:  26/08/2020