Proteases

Recombinant Human Furin

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Product Details

Catalogue Number: 450-47
Description:
Recombinant Human Furin

Proteases (also called Proteolytic Enzymes, Peptidases, or Proteinases) are enzymes that hydrolyze the amide bonds within proteins or peptides. Most proteases act in a specific manner, hydrolyzing bonds at, or adjacent to specific residues or a specific sequence of residues contained within the substrate protein or peptide. Proteases play an important role in most diseases and biological processes, including prenatal and postnatal development, reproduction, signal transduction, the immune response, various autoimmune and degenerative diseases, and cancer. They are also an important research tool, frequently used in the analysis and production of proteins.  Furin is a calcium-dependent serine endoprotease that processes numerous proproteins of different secretory pathways into their mature forms by cleaving at the carboxyl side of the recognition sequence, R-Xaa-(K/R)-R, where Xaa can be any amino acid.  Recombinant Human Furin is a 63.9 kDa protein, corresponding to residues 131 through 715 of the Furin precursor, plus a C-terminal His-tag.

Source: Hi-5 Insect cells

Synonyms: FUR, PACE, PCSK3

AA Sequence: DLNVKAAWAQ GYTGHGIVVS ILDDGIEKNH PDLAGNYDPG ASFDVNDQDP DPQPRYTQMN DNRHGTRCAG EVAAVANNGV CGVGVAYNAR IGGVRMLDGE VTDAVEARSL GLNPNHIHIY SASWGPEDDG KTVDGPARLA EEAFFRGVSQ GRGGLGSIFV WASGNGGREH DSCNCDGYTN SIYTLSISSA TQFGNVPWYS EACSSTLATT YSSGNQNEKQ IVTTDLRQKC TESHTGTSAS APLAAGIIAL TLEANKNLTW RDMQHLVVQT SKPAHLNAND WATNGVGRKV SHSYGYGLLD AGAMVALAQN WTTVAPQRKC IIDILTEPKD IGKRLEVRKT VTACLGEPNH ITRLEHAQAR LTLSYNRRGD LAIHLVSPMG TRSTLLAARP HDYSADGFND WAFMTTHSWD EDPSGEWVLE IENTSEANNY GTLTKFTLVL YGTAPEGLPV PPESSGCKTL TSSQACVVCE EGFSLHQKSC VQHCPPGFAP QVLDTHYSTE NDVETIRASV CAPCHACSAT CQGPALTDCL SCPSHASLDP VEQTCSRQSQ SSRESPPQQQ PPRLPPEVEA GQRLRAGLLP SHLPEHHHHH HHH

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Measured by its ability to cleave the fluorogenic peptide substrate Boc-Arg-Val-Arg-Arg-AMC (Bachem Catalog# I-1645.0025).

Calculated Molecular Weight: 63.9 kDa

Accession Number: P09958

Gene ID: 5045

Note:

50μg is the largest vial size for this product.
Larger sizes supplied as multiple 50μg vials.

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Lood, C
Title
TLR7/8 activation in neutrophils impairs immune complex phagocytosis through shedding of FcgRIIA.
Citation
The Journal of Experimental Medicine; 214(7) pg2103-2119
PubMed Id
First Author
Oleaga, C
Title
Insights into the kinetics and dynamics of the furin-cleaved form of PCSK9.
Citation
Journal of Lipid Research; 62 pg100003
PubMed Id
First Author
Kajiwara, N
Title
Cell-penetrating peptide-mediated cell entry of H5N1 highly pathogenic avian influenza virus.
Citation
Scientific Reports; 10(1) pg18008
PubMed Id