Recombinant Human gAcrp30/Adipolean 0 ReviewsSubmit a Review Product Details Catalogue Number: 450-21 Description: gAcrp30 is a naturally occurring globular protein obtained by proteolytic processing of adiponectin. Adiponectin is produced and secreted exclusively by adipocytes, and is a relatively abundant plasma protein, accounting for up to 0.05% of total serum protein. Like Adiponectin, gAcrp30 is capable of decreasing hyperglycemia and reversing insulin resistance. Additionally, gAcrp30 has been shown to be an important factor in promoting fat loss by signaling muscle to absorb and burn Free-Fatty Acids (FFAs). The signaling receptors for adiponectin and gAcrp30 have recently been identified and named AdipoR1 and AdipoR2. AdipoR2 is predominantly expressed in the liver. Recombinant Human gAcrp30/Adipolean is a 16.6 kDa protein consisting of 145 amino acid residues. Source: E.coli Synonyms: APM-1, Adipolean (human), gad, globular domain of Acrp30 AA Sequence: MKGEPGEGAY VYRSAFSVGL ETYVTIPNMP IRFTKIFYNQ QNHYDGSTGK FHCNIPGLYY FAYHITVYMK DVKVSLFKKD KAMLFTYDQY QENNVDQASG SVLLHLEVGD QVWLQVYGEG ERNGLYADND NDSTFTGFLL YHDTN Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to inhibit the proliferation of murine M1 cells. The expected ED50 for this effect is 1.0-3.0 μg/ml. Calculated Molecular Weight: 16.6 kDa Accession Number: Q15848 Gene ID: 9370 Note: 1mg will be provided as 2x500μg. crossreactivity: Human, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Diabetes/Weight Regulation product.subtitle.recentcitations First Author Dubessy, A Title Role of a Contactin multi-molecular complex secreted by oligodendrocytes in nodal protein clustering in the CNS. Citation Glia; 67(12) pg2248-2263 PubMed Id 31328333 First Author Tilija Pun, N Title Critical role of tristetraprolin and AU-rich element RNA-binding protein 1 in the suppression of cancer cell growth by globular adiponectin. Citation FEBS Open Bio; 8(12) pg1964-1976 PubMed Id 30524947 First Author Hulsmans, M Title Decrease of miR-146b-5p in monocytes during obesity is associated with loss of the anti-inflammatory but not insulin signaling action of adiponectin. Citation PLoS ONE; 7(2) pge32794 PubMed Id 22393448
