Growth Factors & Cytokines

Recombinant Human gAcrp30/Adipolean

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Product Details

Catalogue Number: 450-21
Description:


Recombinant Human gAcrp30/Adipolean

gAcrp30 is a naturally occurring globular protein obtained by proteolytic processing of adiponectin. Adiponectin is produced and secreted exclusively by adipocytes, and is a relatively abundant plasma protein, accounting for up to 0.05% of total serum protein. Like Adiponectin, gAcrp30 is capable of decreasing hyperglycemia and reversing insulin resistance. Additionally, gAcrp30 has been shown to be an important factor in promoting fat loss by signaling muscle to absorb and burn Free-Fatty Acids (FFAs). The signaling receptors for adiponectin and gAcrp30 have recently been identified and named AdipoR1 and AdipoR2. AdipoR2 is predominantly expressed in the liver. Recombinant Human gAcrp30/Adipolean is a 16.6 kDa protein consisting of 145 amino acid residues.

Source: E.coli

Synonyms: APM-1, Adipolean (human), gad, globular domain of Acrp30

AA Sequence: MKGEPGEGAY VYRSAFSVGL ETYVTIPNMP IRFTKIFYNQ QNHYDGSTGK FHCNIPGLYY FAYHITVYMK DVKVSLFKKD KAMLFTYDQY QENNVDQASG SVLLHLEVGD QVWLQVYGEG ERNGLYADND NDSTFTGFLL YHDTN

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to inhibit the proliferation of murine M1 cells. The expected ED50 for this effect is 1.0-3.0 μg/ml.

Calculated Molecular Weight: 16.6 kDa

Accession Number: Q15848

Gene ID: 9370

Note:

1mg will be provided as 2x500μg.

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Park, P
Title
Suppression of lipopolysaccharide-stimulated tumor necrosis factor-alpha production by adiponectin is mediated by transcriptional and post-transcriptional mechanisms.
Citation
The Journal of Biological Chemistry; 283(40) pg26850-8
PubMed Id
First Author
Park, P
Title
Short-term treatment of RAW264.7 macrophages with adiponectin increases tumor necrosis factor-alpha (TNF-alpha) expression via ERK1/2 activation and Egr-1 expression: role of TNF-alpha in adiponectin-stimulated interleukin-10 production.
Citation
The Journal of Biological Chemistry; 282(30) pg21695-703
PubMed Id
First Author
Mandal, P
Title
Adiponectin and heme oxygenase-1 suppress TLR4/MyD88-independent signaling in rat Kupffer cells and in mice after chronic ethanol exposure.
Citation
Journal of immunology (Baltimore, Md. : 1950); 185(8) pg4928-37
PubMed Id