Recombinant Human sFRP-1 0 ReviewsSubmit a Review Product Details Catalogue Number: 120-29 Description: Secreted Frizzled Related Proteins (sFRPs) modulate WNT signaling by binding directly to WNT proteins in a manner that affects their receptor binding and signaling capabilities. sFRP-1 is a widely distributed protein that can bind directly to WNT1, WNT2, and possibly other WNT proteins, and generally exerts anti-proliferative effects consistent with activity as a WNT antagonist. It also inhibits apoptosis, and has been found to be down-regulated in many solid tumors, but up-regulated in uterine leiomyomas. Recombinant Human sFRP-1 is a glycosylated 283 amino acid protein containing a cysteine-rich Frizzled homologous domain. The calculated molecular weight of Recombinant Human sFRP-1 is 32.5 kDa. Source: HeLa cells Synonyms: soluble Frizzled Related Protein-1, Secreted Apoptosis Related Protein-2, SARP-2 AA Sequence: SEYDYVSFQS DIGPYQSGRF YTKPPQCVDI PADLRLCHNV GYKKMVLPNL LEHETMAEVK QQASSWVPLL NKNCHAGTQV FLCSLFAPVC LDRPIYPCRW LCEAVRDSCE PVMQFFGFYW PEMLKCDKFP EGDVCIAMTP PNATEASKPQ GTTVCPPCDN ELKSEAIIEH LCASEFALRM KIKEVKKENG DKKIVPKKKK PLKLGPIKKK DLKKLVLYLK NGADCPCHQL DNLSHHFLIM GRKVKSQYLL TAIHKWDKKN KEFKNFMKKM KNHECPTFQS VFK Purity: ≥ 97% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to inhibit BMP-2 proliferation effect of ATDC-5 cells. The expected ED50 is 0.3–0.5 μg/ml. Calculated Molecular Weight: 32.5 kDa Accession Number: Q8N474 Gene ID: 6422 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Mouse PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest AIDS/HIV Angiogenesis/Cardiovascular Apoptosis Cancer Immune System Stem Cells & Differentiation
