Neurotrophine

Recombinant Human CNTF

Product Details

Catalogue Number: 450-13
Description:

CNTF is a potent neural factor that was originally characterized as a vital factor for the survival of chick ciliary neurons in vitro. CNTF is also important for the survival of other neural cell types, including primary sensory neurons, motor neurons, basal forebrain neurons and type 2 astrocytes. CNTF is highly conserved across species and exhibits cross-species bioactivity. Recombinant Human CNTF is synthesized as a 199 amino acid polypeptide (22.8 kDa) lacking a hydrophobic N-terminal signal for secretion.

Source: E.coli

Synonyms: Ciliary Neurotrophic Factor

AA Sequence: AFTEHSPLTP HRRDLCSRSI WLARKIRSDL TALTQSYVKH QGLNKNINLD SADGMPVAST DQWSQLTQAQ RLQQNLQAYR TFHVLLARLL QDQQVHFTPT QGDFHQAIHT LLLQVAAFAY QIQQLMILLQ YKIPRNQADG MPINVGDGGL FQKKLWGLKV LQQLSQWTVR SIHDLRFISS HQTGIPARGS HYIANNKKM

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to stimulate proliferation of human TF-1 cells using an ED50 concentration range of 50-150 ng/ml.

Calculated Molecular Weight: 22.8 kDa

Accession Number: P26441

Gene ID: 1270

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Hanson, M G
Title
Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro.
Citation
The Journal of neuroscience : the official journal of the Society for Neuroscience; 18(18) pg7361-71
PubMed Id
First Author
Vicario-Abejón, C
Title
Neurotrophins induce formation of functional excitatory and inhibitory synapses between cultured hippocampal neurons.
Citation
The Journal of neuroscience : the official journal of the Society for Neuroscience; 18(18) pg7256-71
PubMed Id
First Author
Back, S A
Title
Maturation-dependent vulnerability of oligodendrocytes to oxidative stress-induced death caused by glutathione depletion.
Citation
The Journal of neuroscience : the official journal of the Society for Neuroscience; 18(16) pg6241-53
PubMed Id