Neurotrophine

Recombinant Human CNTF

0 ReviewsSubmit a Review

Product Details

Catalogue Number: 450-13
Description:


Recombinant Human CNTF

CNTF is a potent neural factor that was originally characterized as a vital factor for the survival of chick ciliary neurons in vitro. CNTF is also important for the survival of other neural cell types, including primary sensory neurons, motor neurons, basal forebrain neurons and type 2 astrocytes. CNTF is highly conserved across species and exhibits cross-species bioactivity. Recombinant Human CNTF is synthesized as a 199 amino acid polypeptide (22.8 kDa) lacking a hydrophobic N-terminal signal for secretion.

Source: E.coli

Synonyms: Ciliary Neurotrophic Factor

AA Sequence: AFTEHSPLTP HRRDLCSRSI WLARKIRSDL TALTQSYVKH QGLNKNINLD SADGMPVAST DQWSQLTQAQ RLQQNLQAYR TFHVLLARLL QDQQVHFTPT QGDFHQAIHT LLLQVAAFAY QIQQLMILLQ YKIPRNQADG MPINVGDGGL FQKKLWGLKV LQQLSQWTVR SIHDLRFISS HQTGIPARGS HYIANNKKM

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to stimulate proliferation of human TF-1 cells using an ED50 concentration range of 50-150 ng/ml.

Calculated Molecular Weight: 22.8 kDa

Accession Number: P26441

Gene ID: 1270

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Ng, T K
Title
Transdifferentiation of periodontal ligament-derived stem cells into retinal ganglion-like cells and its microRNA signature.
Citation
Scientific Reports; 5 pg16429
PubMed Id
First Author
Srikanth, P
Title
Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression.
Citation
Translational Psychiatry; 8(1) pg245
PubMed Id
First Author
Liu, Z
Title
Nucleoporin Seh1 Interacts with Olig2/Brd7 to Promote Oligodendrocyte Differentiation and Myelination.
Citation
Neuron; 102(3) pg587-601.e7
PubMed Id