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Recombinant Human IL-5

Product Details

Catalogue Number: 200-05
Description:

IL-5 is a hematopoietic growth factor that stimulates the proliferation and activation of eosinophils. Produced by mast cells, T cells, and eosinophils, IL-5 plays an important role in inducing cell-mediated immunity against parasitic infections and certain tumors. Elevated levels of IL-5 lead to Eosinophilia, which may result in the induction of asthma and other allergic diseases. Human and murine IL-5 is cross-species reactive. Recombinant Human IL-5 is a 26.5 kDa disulfide-linked homodimeric protein containing two 116 amino acid chains.

Source: E.coli

Synonyms: EDF, BCDFII, TRF

AA Sequence: MIPTEIPTSA LVKETLALLS THRTLLIANE TLRIPVPVHK NHQLCTEEIF QGIGTLESQT VQGGTVERLF KNLSLIKKYI DGQKKKCGEE RRRVNQFLDY LQEFLGVMNT EWIIES

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 as determined by the dose-dependent proliferation of TF-1 cells was ≤ 0.15 ng/ml, corresponding to a specific activity of ≥ 6.6 x 106 units/mg.

Calculated Molecular Weight: 26.5 kDa

Accession Number: P05113

Gene ID: 3567

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Liu, L
Title
Triple role of platelet-activating factor in eosinophil migration across monolayers of lung epithelial cells: eosinophil chemoattractant and priming agent and epithelial cell activator.
Citation
Journal of immunology (Baltimore, Md. : 1950); 161(6) pg3064-70
PubMed Id
First Author
Pieters, T
Title
Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice.
Citation
The Journal of Experimental Medicine; 218(10)
PubMed Id
First Author
Renner, K
Title
Severe T cell hyporeactivity in ventilated COVID-19 patients correlates with prolonged virus persistence and poor outcomes.
Citation
Nature Communications; 12(1) pg3006
PubMed Id