Growth Factors & Cytokines

Recombinant Human IL-5

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Product Details

Catalogue Number: 200-05
Description:


Recombinant Human IL-4

IL-5 is a hematopoietic growth factor that stimulates the proliferation and activation of eosinophils. Produced by mast cells, T cells, and eosinophils, IL-5 plays an important role in inducing cell-mediated immunity against parasitic infections and certain tumors. Elevated levels of IL-5 lead to Eosinophilia, which may result in the induction of asthma and other allergic diseases. Human and murine IL-5 is cross-species reactive. Recombinant Human IL-5 is a 26.5 kDa disulfide-linked homodimeric protein containing two 116 amino acid chains.

Source: E.coli

Synonyms: EDF, BCDFII, TRF

AA Sequence: MIPTEIPTSA LVKETLALLS THRTLLIANE TLRIPVPVHK NHQLCTEEIF QGIGTLESQT VQGGTVERLF KNLSLIKKYI DGQKKKCGEE RRRVNQFLDY LQEFLGVMNT EWIIES

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 as determined by the dose-dependent proliferation of TF-1 cells was ≤ 0.15 ng/ml, corresponding to a specific activity of ≥ 6.6 x 106 units/mg.

Calculated Molecular Weight: 26.5 kDa

Accession Number: P05113

Gene ID: 3567

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Jenkins, M R
Title
Failed CTL/NK cell killing and cytokine hypersecretion are directly linked through prolonged synapse time.
Citation
The Journal of Experimental Medicine; 212(3) pg307-17
PubMed Id
First Author
de Bruin, A M
Title
Eosinophil differentiation in the bone marrow is inhibited by T cell-derived IFN-gamma.
Citation
Blood; 116(14) pg2559-69
PubMed Id
First Author
Pieters, T
Title
Cyclin D2 overexpression drives B1a-derived MCL-like lymphoma in mice.
Citation
The Journal of Experimental Medicine; 218(10)
PubMed Id