Growth Factors & Cytokines

Recombinant Human BAFF

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Product Details

Catalogue Number: 310-13
Description:
Recombinant Human BAFF

BAFF, a member of the TNF family of ligands, is expressed in T cells, macrophages, monocytes and dendritic cells. BAFF is involved in stimulation of B and T cell function, and is an important survival and maturation factor for peripheral B cells. BAFF signals through three different TNF receptors, TACI, BCMA and BAFFR. The human BAFF gene codes for a 285 amino acid type II transmembrane protein containing a 46 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 218 amino acid extracellular domain. Recombinant Human soluble BAFF is a 152 amino acid polypeptide (17.0 kDa), which contains the TNF-like portion of the extracellular domain of BAFF.

Source: E.coli

Synonyms: B cell Activating Factor belonging to the TNF family, TNFSF13B, TNFSF20, TALL-1, BLyS, THANK, ZNTF4

AA Sequence: AVQGPEETVT QDCLQLIADS ETPTIQKGSY TFVPWLLSFK RGSALEEKEN KILVKETGYF FIYGQVLYTD KTYAMGHLIQ RKKVHVFGDE LSLVTLFRCI QNMPETLPNN SCYSAGIAKL EEGDELQLAI PRENAQISLD GDVTFFGALK LL

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by a mouse splenocyte survival assay. The expected ED50 for this effect is 0.5-2.0 µg/ml.

Recombinant Human BAFF Biological Activity Graph

Calculated Molecular Weight: 17 kDa

Accession Number: Q9Y275

Gene ID: 10673

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Sokal, A
Title
mRNA vaccination of naive and COVID-19-recovered individuals elicits potent memory B cells that recognize SARS-CoV-2 variants.
Citation
Immunity; 54(12) pg2893-2907.e5
PubMed Id
First Author
Malinova, D
Title
Endophilin A2 regulates B-cell endocytosis and is required for germinal center and humoral responses
Citation
EMBO reports; 22(9) pge51328
PubMed Id
First Author
Monzón-Casanova, E
Title
Essential requirement for polypyrimidine tract binding proteins 1 and 3 in the maturation and maintenance of mature B cells in mice.
Citation
European Journal of Immunology; 51(9) pg2266-2273
PubMed Id