Growth Factors & Cytokines

Recombinant Murine IL-22

Product Details

Catalogue Number: 210-22
Description:

IL-22 is a member of the IL-10 family of regulatory cytokines, which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26.  Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions.  Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas.  IL-22 signals through a receptor system consisting of IL-10Rβ/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family.  Recombinant Murine IL-22 is a 33.4 kDa, non-disulfide-linked, homodimeric protein consisting of two 147 amino acid polypeptide chains.

Source: E.coli

Synonyms: Interleukin-22, IL-TIF, Cytokine ZCYTO18

AA Sequence (monomer): MLPVNTRCKL EVSNFQQPYI VNRTFMLAKE ASLADNNTDV RLIGEKLFRG VSAKDQCYLM KQVLNFTLED VLLPQSDRFQ PYMQEVVPFL TKLSNQLSSC HISGDDQNIQ KNVRRLKETV KKLGESGEIK AIGELDLLFM SLRNACV

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to induce STAT3 activation in COLO 205 cells. The expected ED50 for this effect is 150-400 pg/ml.

Calculated Molecular Weight: 33.4 kDa

Accession Number: Q9JJY9

Gene ID: 50929

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Melin, N
Title
Synergistic effect of the TLR5 agonist CBLB502 and its downstream effector IL-22 against liver injury.
Citation
Cell death & disease; 12(4) pg366
PubMed Id
First Author
Lindborg, J A
Title
Optic nerve regeneration screen identifies multiple genes restricting adult neural repair.
Citation
Cell Reports; 34(9) pg108777
PubMed Id
First Author
Shao, L
Title
IL-22 ameliorates LPS-induced acute liver injury by autophagy activation through ATF4-ATG7 signaling
Citation
Cell Death & Disease; 11(11) pg970
PubMed Id