Recombinant Human TIMP-1 0 ReviewsSubmit a Review Product Details Catalogue Number: 410-01 Description: TIMP-1 is an extracellular inhibitor of MMPs, including MMP-1, -2, -3, -7, -8, -9, -10, -11, -12, -13, and -16. It belongs to the I35 (TIMP) family of irreversible protease inhibitors that function as key modulators of extracellular matrix degradation during tissue development and remodeling. TIMP-1 can also act through an MMP-independent mechanism to promote erythropoiesis by stimulating proliferation and differentiation of erythroid progenitors. Recombinant Human TIMP-1 is a 20.6 kDa protein containing 184 amino acid residues. Source: E.coli Synonyms: Tissue inhibitor of metalloproteinases, Fibroblast collagenase inhibitor, Erythroid-potentiating activity AA Sequence: CTCVPPHPQT AFCNSDLVIR AKFVGTPEVN QTTLYQRYEI KMTKMYKGFQ ALGDAADIRF VYTPAMESVC GYFHRSHNRS EEFLIAGKLQ DGLLHITTCS FVAPWNSLSL AQRRGFTKTY TVGCEECTVF PCLSIPCKLQ SGTHCLWTDQ LLQGSEKGFQ SRHLACLPRE PGLCTWQSLR SQIA Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: TIMP-1 activity was measured by its ability to inhibit human MMP-1-induced hydrolysis of a chromogenic peptide substrate at room temperature. Half maximal inhibition was obtained at a TIMP-1 concentration of approximately 0.5 μg/ml, when using an MMP-1 concentration of 1.6 μg/ml. Calculated Molecular Weight: 20.6 kDa Accession Number: P01033 Gene ID: 7076 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Cancer Immune System Inflammation Neurobiology Stem Cells & Differentiation product.subtitle.recentcitations First Author Park, S Title TIMP-1 mediates TGF-β-dependent crosstalk between hepatic stellate and cancer cells via FAK signaling. Citation Scientific Reports; 5 pg16492 PubMed Id 26549110 First Author Egea, V Title Tissue inhibitor of metalloproteinase-1 (TIMP-1) regulates mesenchymal stem cells through let-7f microRNA and Wnt/β-catenin signaling. Citation Proceedings of the National Academy of Sciences of the United States of America; 109(6) pgE309-16 PubMed Id 22223664
