Growth Factors & Cytokines

Recombinant Rat IL-13 (109 a.a.)

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Product Details

Catalogue Number: 400-16
Description:

IL-13 is an immunoregulatory cytokine produced primarily by activated Th2 cells, and also by mast cells and NK cells.  Targeted deletion of IL-13 in mice resulted in impaired Th2 cell development and indicated an important role for IL-13 in the expulsion of gastrointestinal parasites.  IL-13 exerts anti-inflammatory effects on monocytes and macrophages and it inhibits the expression of inflammatory cytokines such as IL-1β, TNF-α, IL-6 and IL-8.  IL-13 has also been shown to enhance B cell proliferation and to induce isotype switching, resulting in increased production of IgE.  Blocking of IL-13 activity inhibits the pathophysiology of asthma.  Human and murine IL-13 are cross-species reactive.  Recombinant Rat IL-13 is an 11.9 kDa protein consisting of 109 amino acid residues.

Source: E.coli

Synonyms: NC300 (Human), P600 (Murine)

AA Sequence: VRRSTSPPVA LRELIEELSN ITQDQKTSLC NSSMVWSVDL TAGGFCAALE SLTNISSCNA IHRTQRILNG LCNQKASDVA SSPPDTKIEV AQFISKLLNY SKQLFRYGH

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 as determined by the dose-dependant stimulation of the proliferation of human TF-1 cells is ≤ 40 ng/ml, corresponding to a specific activity of ≥ 2.5 x 104 units/mg.

Calculated Molecular Weight: 11.9 kDa

Accession Number: P42203

Gene ID: 116553

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Yang, M
Title
Interleukin-13 enhances cyclooxygenase-2 expression in activated rat brain microglia: implications for death of activated microglia.
Citation
Journal of immunology (Baltimore, Md. : 1950); 177(2) pg1323-9
PubMed Id
First Author
Shimizu, E
Title
IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia.
Citation
Journal of immunology (Baltimore, Md. : 1950); 181(9) pg6503-13
PubMed Id
First Author
Bhushan, S
Title
Uropathogenic E. coli induce different immune response in testicular and peritoneal macrophages: implications for testicular immune privilege.
Citation
PLoS ONE; 6(12) pge28452
PubMed Id