Growth Factors & Cytokines

Recombinant Human 4-1BB Ligand

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Product Details

Catalogue Number: 310-11
Description:


Recombinant Human 4-1BB Ligand

4-1BBL, a member of the TNF superfamily, is expressed in B cells, dendritic cells, activated T cells and macrophages. 4-1BBL binds to its receptor 4-1BB, and provides a co-stimulatory signal for T cell activation and expansion. The human 4-1BBL gene codes for a 254 amino acid type II transmembrane containing a 28 amino acid cytoplasmic domain, a 21 amino acid transmembrane protein domain, and a 205 amino acid extracellular domain. The soluble form of 4-1BBL contains the TNF-like portion of the extracellular domain of 4-1BBL. Recombinant Human 4-1BBL is a soluble 19.5 kDa protein consisting of 185 amino acid residues.

Source: E.coli

Synonyms: TNFSF9, CD137L

AA Sequence: MREGPELSPD DPAGLLDLRQ GMFAQLVAQN VLLIDGPLSW YSDPGLAGVS LTGGLSYKED TKELVVAKAG VYYVFFQLEL RRVVAGEGSG SVSLALHLQP LRSAAGAAAL ALTVDLPPAS SEARNSAFGF QGRLLHLSAG QRLGVHLHTE ARARHAWQLT QGATVLGLFR VTPEIPAGLP SPRSE

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by the dose-dependent stimulation of IL-8 production by human PBMC. The ED50 for this effect is 5-10 ng/ml.
 Please Note: Results may vary with PBMC donors.

Calculated Molecular Weight: 19.5 kDa

Accession Number: P41273

Gene ID: 8744

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Kirouac, D C
Title
Dynamic interaction networks in a hierarchically organized tissue.
Citation
Molecular Systems Biology; 6 pg417
PubMed Id
First Author
Houtenbos, I
Title
Leukemia-specific T-cell reactivity induced by leukemic dendritic cells is augmented by 4-1BB targeting.
Citation
Clinical cancer research : an official journal of the American Association for Cancer Research; 13(1) pg307-15
PubMed Id
First Author
Hulley, P A
Title
Hypoxia-inducible factor 1-alpha does not regulate osteoclastogenesis but enhances bone resorption activity via prolyl-4-hydroxylase 2.
Citation
The Journal of Pathology; 242(3) pg322-333
PubMed Id