Growth Factors & Cytokines

Recombinant Human CYR61

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Product Details

Catalogue Number: 120-25
Description:


Recombinant Human CYR61

CYR61 is a member of the CCN family of secreted cysteine-rich regulatory proteins. CYR61 induces angiogenesis by stimulating the proliferation, migration, and adhesion of endothelial cells. Cell migration and adhesion are mediated through binding to specific cell surface integrins and to heparin sulfate proteoglycans. Increased expression of CYR61 is associated with several types of cancer, and correlates with the progression and estrogen independence of human breast cancers. Recombinant Human CYR61 is a 39.5 kDa protein containing 357 amino acid residues. It is composed of four distinct structural domains (modules); the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the Thrombospondin type-I (TSP type-1) domain, and a C-terminal cysteine knot-like domain (CTCK).

Source: E.coli

Synonyms: Cellular Communication Network Factor 1 (CCN1), GIG1 protein, Cysteine-rich angiogenic inducer 61, IGF-BP10

AA Sequence: TCPAACHCPL EAPKCAPGVG LVRDGCGCCK VCAKQLNEDC SKTQPCDHTK GLECNFGASS TALKGICRAQ SEGRPCEYNS RIYQNGESFQ PNCKHQCTCI DGAVGCIPLC PQELSLPNLG CPNPRLVKVT GQCCEEWVCD EDSIKDPMED QDGLLGKELG FDASEVELTR NNELIAVGKG SSLKRLPVFG MEPRILYNPL QGQKCIVQTT SWSQCSKTCG TGISTRVTND NPECRLVKET RICEVRPCGQ PVYSSLKKGK KCSKTKKSPE PVRFTYAGCL SVKKYRPKYC GSCVDGRCCT PQLTRTVKMR FRCEDGETFS KNVMMIQSCK CNYNCPHANE AAFPFYRLFN DIHKFRD

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by the dose-dependent stimulation of the proliferation of murine 3T3 cells. The expected ED50 for this effect is 2.0-3.0 μg/ml.

Calculated Molecular Weight: 39.4 kDa

Accession Number: O00622

Gene ID: 3491

Note:

1mg will be provided as 2x500μg.

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Francischetti, I M
Title
Cyr61/CCN1 displays high-affinity binding to the somatomedin B(1-44) domain of vitronectin.
Citation
PLoS ONE; 5(2) pge9356
PubMed Id
First Author
Yu, Y
Title
Novel Biological Substrates of Human Kallikrein 7 Identified through Degradomics.
Citation
The Journal of Biological Chemistry; 290(29) pg17762-75
PubMed Id
First Author
Morrell, E D
Title
Alveolar CCN1 is associated with mechanical stretch and acute respiratory distress syndrome severity.
Citation
American Journal of Physiology. Lung Cellular and Molecular Physiology; 319(5) pgL825-L832
PubMed Id