Recombinant Human IFN-ω 0 ReviewsSubmit a Review Product Details Catalogue Number: 300-02J Description: IFN-ω is a type I interferon that can be induced by virus-infected leukocytes. Members of the type I interferon family, which includes IFN-α, IFN-β, and IFN-ω, signal through the IFNAR-1/IFNAR-2 receptor complex, and exert antiviral and antiproliferative activities. IFN-ω exhibits about 75% sequence homology with IFN-α, and contains two conserved disulfide bonds that are necessary for full biological activity. Recombinant Human IFN-ω is a 19.9 kDa protein consisting of 172 amino acid residues. Source: E.coli Synonyms: IFN alpha II-1, IFNW1 AA Sequence: CDLPQNHGLL SRNTLVLLHQ MRRISPFLCL KDRRDFRFPQ EMVKGSQLQK AHVMSVLHEM LQQIFSLFHT ERSSAAWNMT LLDQLHTGLH QQLQHLETCL LQVVGEGESA GAISSPALTL RRYFQGIRVY LKEKKYSDCA WEVVRMEIMK SLFLSTNMQE RLRSKDRDLG SS Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 was determined by a cytotoxicity assay using Human TF-1 cells is ≤ 0.01 ng/ml, corresponding to a specific activity of ≥ 1 x 108 units/mg. Calculated Molecular Weight: 19.9 kDa Accession Number: P05000 Gene ID: 3467 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse, References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Immune System Inflammation product.subtitle.recentcitations First Author Wang, J Title Alpha-Soluble NSF Attachment Protein Prevents the Cleavage of the SARS-CoV-2 Spike Protein by Functioning as an Interferon-Upregulated Furin Inhibitor. Citation mBio; pge0244321 PubMed Id 35012335 First Author Rodero, M P Title Detection of interferon alpha protein reveals differential levels and cellular sources in disease. Citation The Journal of Experimental Medicine; 214(5) pg1547-1555 PubMed Id 28420733 First Author Walter, J E Title Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency. Citation The Journal of Clinical Investigation; 125(11) pg4135-48 PubMed Id 26457731
