Recombinant Human sTNF Receptor Type I 0 ReviewsSubmit a Review Product Details Catalogue Number: 310-07 Description: TNFRI belongs to the TNFR superfamily of transmembrane proteins, and is expressed in most cell types. Binding of either TNF-α or TNF-β to TNFRI initiates a signal transduction pathway that results in the activation of the transduction factor NF-κB, whose target genes are involved in the regulation of inflammatory responses, and, in certain cells induce apoptosis. Soluble TNF Receptor I (sTNFRI) is capable of inhibiting TNF-α and TNF-β activities by acting as a decoy receptor that serves as a sink for the TNF ligands. The human TNFRI gene encodes for a 455 amino acid type I transmembrane protein, which contains a 21 amino acid signal sequence, a 190 amino acid extracellular domain, a 23 amino acid transmembrane domain, and a 221 amino acid cytoplasmic domain. Recombinant Human sTNF Receptor Type I is an 18.3 kDa protein (162 amino acid residues) comprising the cysteine-rich, ligand-binding portion of the extracellular domain of the TNFRI protein. Source: E.coli Synonyms: Soluble Tumor Necrosis Factor Type I, TNFRSF1A, TNFAR, TNFR60, p55, CD120a AA Sequence: MDSVCPQGKY IHPQNNSICC TKCHKGTYLY NDCPGPGQDT DCRECESGSF TASENHLRHC LSCSKCRKEM GQVEISSCTV DRDTVCGCRK NQYRHYWSEN LFQCFNCSLC LNGTVHLSCQ EKQNTVCTCH AGFFLRENEC VSCSNCKKSL ECTKLCLPQI EN Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its inhibitory effect of the TNF-α mediated cytotoxicity in murine L-929 cells. The ED50 for this effect in the presence of 0.25 ng/ml of recombinant human TNF-α, is 0.05 µg/ml. Calculated Molecular Weight: 18.3 kDa Accession Number: P19438 Note: 1mg will be provided as 2x500μg. Gene ID: 7132 crossreactivity: Alpaca, Human, Mouse, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Apoptosis Immune System Inflammation Neurobiology Receptors Stem Cells & Differentiation TNF Superfamily product.subtitle.recentcitations First Author Zheng, Z Title Screening of an anti-inflammatory peptide from Hydrophis cyanocinctus and analysis of its activities and mechanism in DSS-induced acute colitis. Citation Scientific Reports; 6 pg25672 PubMed Id 27158082 First Author Barlic, J Title Atherogenic lipids induce adhesion of human coronary artery smooth muscle cells to macrophages by up-regulating chemokine CX3CL1 on smooth muscle cells in a TNFalpha-NFkappaB-dependent manner. Citation The Journal of Biological Chemistry; 282(26) pg19167-76 PubMed Id 17456471 First Author Zheng, W Title Glial TNFα in the spinal cord regulates neuropathic pain induced by HIV gp120 application in rats. Citation Molecular Pain; 7 pg40 PubMed Id 21599974