Growth Factors & Cytokines

Recombinant Murine G-CSF

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Product Details

Catalogue Number: 250-05
Description:


Recombinant Murine G-CSF

G-CSF is a hematopoietic growth factor that stimulates the development of committed progenitor cells to neutrophils and enhances the functional activities of the mature end-cell. It is produced in response to specific stimulation by a variety of cells, including macrophages, fibroblasts, endothelial cells and bone marrow stroma. G-CSF is being used clinically to facilitate hematopoietic recovery after bone marrow transplantation. Human and murine G-CSF are cross-species reactive. Recombinant Murine G-CSF is a 19.0 kDa protein consisting of 179 amino acid residues.

Source: E.coli

Synonyms: Granulocyte Colony-Stimulating Factor, CSF-3, MGI-1G, GM-CSFb, pluripoietin

AA Sequence: MVPLVTVSAL PPSLPLPRSF LLKSLEQVRK IQASGSVLLE QLCATYKLCH PEELVLLGHS LGIPKASLSG CSSQALQQTQ CLSQLHSGLC LYQGLLQALS GISPALAPTL DLLQLDVANF ATTIWQQMEN LGVAPTVQPT QSAMPAFTSA FQRRAGGVLA ISYLQGFLET ARLALHHLA

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of murine NFS-60 cells is ≤  0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.

Calculated Molecular Weight: 19 kDa

Accession Number: P09920

Gene ID: 12985

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
de Bruin, A M
Title
IFNγ induces monopoiesis and inhibits neutrophil development during inflammation.
Citation
Blood; 119(6) pg1543-54
PubMed Id
First Author
Gan, B
Title
mTORC1-dependent and -independent regulation of stem cell renewal, differentiation, and mobilization.
Citation
Proceedings of the National Academy of Sciences of the United States of America; 105(49) pg19384-9
PubMed Id
First Author
van Oosten, A L
Title
JAK/STAT3 signalling is sufficient and dominant over antagonistic cues for the establishment of naive pluripotency.
Citation
Nature Communications; 3 pg817
PubMed Id