Recombinant Human IL-23 0 ReviewsSubmit a Review Product Details Catalogue Number: 200-23 Description: IL-23 is a proinflammatory, heterodimeric protein composed of two subunits: a unique p19 subunit, and a p40 subunit that is shared with IL-12. IL-23 is secreted by activated dendritic cells and macrophages, and signals though a receptor comprised of IL-23R complexed with IL-12Rβ1. IL-23 has been shown to enhance proliferation of memory T cells. It also stimulates the production of IFN-γ in NK cells, induces IL-17 production, and drives Th17-mediated responses. Recombinant Human IL-23 is a 53.5 kDa, heterodimeric protein consisting of the two subunits, p19 (170 amino acids) and p40 (306 amino acids). Source: (BTI-Tn-5B1-4) Hi-5 Insect cells Synonyms: Interleukin-23 AA Sequence: p19 Subunit: RAVPGGSSPA WTQCQQLSQK LCTLAWSAHP LVGHMDLREE GDEETTNDVP HIQCGDGCDP QGLRDNSQFC LQRIHQGLIF YEKLLGSDIF TGEPSLLPDS PVGQLHASLL GLSQLLQPEG HHWETQQIPS LSPSQPWQRL LLRFKILRSL QAFVAVAARV FAHGAATLSP p40 Subunit: IWELKKDVYV VELDWYPDAP GEMVVLTCDT PEEDGITWTL DQSSEVLGSG KTLTIQVKEF GDAGQYTCHK GGEVLSHSLL LLHKKEDGIW STDILKDQKE PKNKTFLRCE AKNYSGRFTC WWLTTISTDL TFSVKSSRGS SDPQGVTCGA ATLSAERVRG DNKEYEYSVE CQEDSACPAA EESLPIEVMV DAVHKLKYEN YTSSFFIRDI IKPDPPKNLQ LKPLKNSRQV EVSWEYPDTW STPHSYFSLT FCVQVQGKSK REKKDRVFTD KTSATVICRK NASISVRAQD RYYSSSWSEW ASVPCS Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses. Biological Activity: Measured by its ability to induce IL-17 secretion by mouse splenocytes. Calculated Molecular Weight: 53.5 kDa Accession Number: p19: Q9NPF7 p40: P29460 Gene ID: p19: 51561 p40: 3593 Note: 1mg will be provided as 2x500μg. crossreactivity: Human, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Cancer Immune System Inflammation Neurobiology Allergy product.subtitle.recentcitations First Author Malik, S Title Transcription factor Foxo1 is essential for IL-9 induction in T helper cells. Citation Nature Communications; 8(1) pg815 PubMed Id 28993609 First Author Zhao, M Title IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation. Citation Nature Communications; 9(1) pg583 PubMed Id 29422534 First Author Chen, J Title Interaction of RNA-binding protein HuR and miR-466i regulates GM-CSF expression. Citation Scientific Reports; 7(1) pg17233 PubMed Id 29222492
