Growth Factors & Cytokines

Recombinant Human IL-23

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Product Details

Catalogue Number: 200-23
Description:
Recombinant Human IL-23

IL-23 is a proinflammatory, heterodimeric protein composed of two subunits: a unique p19 subunit, and a p40 subunit that is shared with IL-12. IL-23 is secreted by activated dendritic cells and macrophages, and signals though a receptor comprised of IL-23R complexed with IL-12Rβ1. IL-23 has been shown to enhance proliferation of memory T cells. It also stimulates the production of IFN-γ in NK cells, induces IL-17 production, and drives Th17-mediated responses. Recombinant Human IL-23 is a 53.5 kDa, heterodimeric protein consisting of the two subunits, p19 (170 amino acids) and p40 (306 amino acids).

Source: (BTI-Tn-5B1-4) Hi-5 Insect cells

Synonyms: Interleukin-23

AA Sequence: p19 Subunit: RAVPGGSSPA WTQCQQLSQK LCTLAWSAHP LVGHMDLREE GDEETTNDVP HIQCGDGCDP QGLRDNSQFC LQRIHQGLIF YEKLLGSDIF TGEPSLLPDS PVGQLHASLL GLSQLLQPEG HHWETQQIPS LSPSQPWQRL LLRFKILRSL QAFVAVAARV FAHGAATLSP

p40 Subunit: IWELKKDVYV VELDWYPDAP GEMVVLTCDT PEEDGITWTL DQSSEVLGSG KTLTIQVKEF GDAGQYTCHK GGEVLSHSLL LLHKKEDGIW STDILKDQKE PKNKTFLRCE AKNYSGRFTC WWLTTISTDL TFSVKSSRGS SDPQGVTCGA ATLSAERVRG DNKEYEYSVE CQEDSACPAA EESLPIEVMV DAVHKLKYEN YTSSFFIRDI IKPDPPKNLQ LKPLKNSRQV EVSWEYPDTW STPHSYFSLT FCVQVQGKSK REKKDRVFTD KTSATVICRK NASISVRAQD RYYSSSWSEW ASVPCS

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Measured by its ability to induce IL-17 secretion by mouse splenocytes.

Calculated Molecular Weight: 53.5 kDa

Accession Number: p19: Q9NPF7 p40: P29460

Gene ID: p19: 51561 p40: 3593

Note:

1mg will be provided as 2x500μg.

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Krzywinska, E
Title
The transcription factor HIF-1α mediates plasticity of NKp46+ innate lymphoid cells in the gut.
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The Journal of Experimental Medicine; 219(2)
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Jang, Y
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Lactoferrin Potentiates Inducible Regulatory T Cell Differentiation through TGF-β Receptor III Binding and Activation of Membrane-Bound TGF-β.
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Journal of immunology (Baltimore, Md. : 1950); 207(10) pg2456-2464
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Liu, C
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Delineating spatiotemporal and hierarchical development of human fetal innate lymphoid cells
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Cell Research; 31(10) pg1106-1122
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