Animal-Free Recombinant Human 4-1BB Ligand 0 ReviewsSubmit a Review Product Details Catalogue Number: AF-310-11 Description: 4‐1BBL, a member of the TNF superfamily, is expressed in B cells, dendritic cells, activated T cells andmacrophages. 4‐1BBL binds to its receptor 4‐1BB, and provides a co‐stimulatory signal for T cell activation and expansion. The human 4‐1BBL gene codes for a 254 amino acid type II transmembrane protein containing a 28 amino acid cytoplasmic domain, a 21 amino acid transmembrane protein domain, and a 205 amino acid extracellular domain. The soluble form of 4‐1BBL contains the TNF‐like portion of the extracellular domain of 4‐1BBL. Recombinant Human 4‐1BB Ligand is a soluble 19.5 kDa protein consisting of 185 amino acid residues. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: TNFSF9, CD137L AA Sequence: MREGPELSPD DPAGLLDLRQ GMFAQLVAQN VLLIDGPLSW YSDPGLAGVS LTGGLSYKED TKELVVAKAG VYYVFFQLEL RRVVAGEGSG SVSLALHLQP LRSAAGAAAL ALTVDLPPAS SEARNSAFGF QGRLLHLSAG QRLGVHLHTE ARARHAWQLT QGATVLGLFR VTPEIPAGLP SPRSE Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to induce CD137/NF-κB activation in HEK293 reporter cells. Calculated Molecular Weight: 19.5 kDa Accession Number: P41273 Gene ID: 8744 Endotoxin: Endotoxin level is < 0.01 ng/ug of protein (< 0.1 EU/ug) PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Angiogenesis/Cardiovascular Apoptosis Immune System TNF Superfamily Transplantation
