Growth Factors & Cytokines

Recombinant Human Follistatin

0 ReviewsSubmit a Review

Product Details

Catalogue Number: 120-13
Description:

Follistatin is a secreted protein that binds to ligands of the TGF-β family and regulates their activity by inhibiting their access to signaling receptors. It was originally discovered as an activin antagonist whose activity suppresses expression and secretion of the pituitary hormone FSH (follicle stimulating hormone). In addition to being a natural antagonist, follistatin can inhibit the activity of other TGF-β ligands including BMP-2,-4,-6,-7, Myostatin, GDF-11, and TGF-β1. Follistatin is expressed in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues. Recombinant Human Follistatin is a 31.5 kDa protein containing 288 amino acids. Its primary structure contains three cysteine-rich domains (called FS domains), each followed by a protease-inhibitory kazal domain.

Source: E.coli

Synonyms: FS, Activin-binding protein

AA Sequence: GNCWLRQAKN GRCQVLYKTE LSKEECCSTG RLSTSWTEED VNDNTLFKWM IFNGGAPNCI PCKETCENVD CGPGKKCRMN KKNKPRCVCA PDCSNITWKG PVCGLDGKTY RNECALLKAR CKEQPELEVQ YQGRCKKTCR DVFCPGSSTC VVDQTNNAYC VTCNRICPEP ASSEQYLCGN DGVTYSSACH LRKATCLLGR SIGLAYEGKC IKAKSCEDIQ CTGGKKCLWD FKVGRGRCSL CDELCPDSKS DEPVCASDNA TYASECAMKE AACSSGVLLE VKHSGSCN

Purity: ≥ 95% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to neutralize Activin A inhibitory effect of murine MPC-11 cells. The expected ED50 is 0.1-0.4 µg/ml in the presence of 7.5 ng/ml Activin A.

Calculated Molecular Weight: 31.5 kDa

Accession Number: P19883

Gene ID: 10468

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Harrington, A E
Title
Structural basis for the inhibition of activin signalling by follistatin.
Citation
The EMBO Journal; 25(5) pg1035-45
PubMed Id
First Author
Cangkrama, M
Title
A paracrine activin A-mDia2 axis promotes squamous carcinogenesis via fibroblast reprogramming.
Citation
EMBO Molecular Medicine; 12(4) pge11466
PubMed Id
First Author
Yucer, N
Title
Directed Differentiation of Human Induced Pluripotent Stem Cells into Fallopian Tube Epithelium.
Citation
Scientific Reports; 7(1) pg10741
PubMed Id