Growth Factors & Cytokines

Recombinant Human M-CSF

Product Details

Catalogue Number: 300-25
Description:

M-CSF is a potent hematopoietic factor produced by a variety of cells, including lymphocytes, monocytes, fibroblasts, endothelial cells, myoblasts and osteoblasts. It is a key regulator of cellular proliferation, differentiation, and survival for blood monocytes, tissue macrophages, and their respective progenitor cells. M-CSF has been shown to play important roles in modulating dermal thickness and fertility. M-CSF is clinically used in the treatment of infection, malignancies and atherosclerosis. It facilitates hematopoietic recovery after bone marrow transplantation. Human M-CSF is reactive in murine systems, but the murine molecule exhibits no activity on human cells. Recombinant Human M-CSF is a 36.8 kDa homodimeric protein consisting of two 159 amino acid polypeptide subunits.

Source: E.coli

Synonyms: Macrophage Colony Stimulating Factor, CSF-1, MGI-IM

AA Sequence (monomer): MEEVSEYCSH MIGSGHLQSL QRLIDSQMET SCQITFEFVD QEQLKDPVCY LKKAFLLVQD IMEDTMRFRD NTPNAIAIVQ LQELSLRLKS CFTKDYEEHD KACVRTFYET PLQLLEKVKN VFNETKNLLD KDWNIFSKNC NNSFAECSSQ GHERQSEGS

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of murine M-NSF-60 cells ≤ 1 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.

Calculated Molecular Weight: 36.8 kDa

Accession Number: P09603

Gene ID: 1435

crossreactivity:
Country Of Origin: USA

Not for human use.

Country Of Origin: USA

Not for human use.

product.subtitle.productreviews

Existing reviews
Great Product
It is a great product for my study. I had used this product in several cell-line experiments including primary cell lines.
From:  Kanagavel | Date:  22/07/2020
Perfect for macrophages
M-CSF is wonderful for macrophage tissue culture.
From:  Heather | Date:  03/08/2021
Best MCSF on the market
My lab switched to Peprotech a few years ago for human MCSF and we will never go back. We generate human macrophages with this product and have only had consistent and great results. It's also competively priced for the quantity and so I'd definitely recommend it.
From:  Emilio | Date:  04/08/2021