Neurotrophins

Recombinant Human Midkine

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Product Details

Catalogue Number: 450-16
Description:

Midkine (MK) and the functionally-related protein pleiotrophin are heparin-binding neurotrophic factors that signal through the same receptor, known as anaplastic lymphoma kinase (ALK).  MK plays an important regulatory role in epithelial-mesenchymal interactions during fetal development and in postnatal lung development.  MK chemoattracts embryonic neurons, neutrophils and macrophages, and exerts angiogenic, growth and survival activities during tumorigenesis.  Recombinant Human Midkine is a 13.4 kDa protein containing 123 amino acid residues including five intra-molecular disulfide bonds.

Source: E.coli

Synonyms: MK, NEGF-2

AA Sequence: VAKKKDKVKK GGPGSECAEW AWGPCTPSSK DCGVGFREGT CGAQTQRIRC RVPCNWKKEF GADCKYKFEN WGACDGGTGT KVRQGTLKKA RYNAQCQETI RVTKPCTPKT KAKAKAKKGK GKD

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human neutrophils using a concentration range of 0.1-10.0 ng/ml.

Calculated Molecular Weight: 13.4 kDa

Accession Number: P21741

Gene ID: 4192

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Weckbach, L T
Title
Midkine drives cardiac inflammation by promoting neutrophil trafficking and NETosis in myocarditis.
Citation
The Journal of Experimental Medicine; 216(2) pg350-368
PubMed Id
First Author
Deepa, S S
Title
Chondroitin sulfate chains on syndecan-1 and syndecan-4 from normal murine mammary gland epithelial cells are structurally and functionally distinct and cooperate with heparan sulfate chains to bind growth factors. A novel function to control binding of midkine, pleiotrophin, and basic fibroblast growth factor.
Citation
The Journal of Biological Chemistry; 279(36) pg37368-76
PubMed Id
First Author
Nandini, C D
Title
Structural and functional characterization of oversulfated chondroitin sulfate/dermatan sulfate hybrid chains from the notochord of hagfish. Neuritogenic and binding activities for growth factors and neurotrophic factors.
Citation
The Journal of Biological Chemistry; 279(49) pg50799-809
PubMed Id