Recombinant Human I-309 (CCL1) 0 ReviewsSubmit a Review Product Details Catalogue Number: 300-37 Description: I-309 is a CC chemokine that signals through the CCR8 receptor. It is secreted by T-lymphocytes, monocytes and mast cells. I-309 chemoattracts monocytes and Th2 differentiated T-cells, but not neutrophils. Human I-309 is active on murine cells. Recombinant Human I-309 is an 8.5 kDa protein consisting of 74 amino acid residues that include six cysteine residues, of which four are the highly conserved cysteine residues present in CC chemokines. Unlike some CC chemokines, whose biologically active form in solution is a non-disulfide-linked dimer, the biologically active form of I-309 is monomeric. Source: E.coli Synonyms: CCL1, TCA-3 AA Sequence: SKSMQVPFSR CCFSFAEQEI PLRAILCYRN TSSICSNEGL IFKLKRGKEA CALDTVGWVQ RHRKMLRHCP SKRK Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract human monocytes population using a concentration range of 10.0-30.0 ng/ml. Calculated Molecular Weight: 8.5 kDa Accession Number: P22362 Gene ID: 6346 crossreactivity: Bacteria, Human, Monkey, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest Chemotaxis Immune System Neurobiology Wound Healing product.subtitle.recentcitations First Author Barington, L Title Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding. Citation The Journal of Biological Chemistry; 291(31) pg16208-20 PubMed Id 27226537 First Author Yasuoka, H Title Increased both PD-L1 and PD-L2 expressions on monocytes of patients with hepatocellular carcinoma was associated with a poor prognosis Citation Scientific Reports; 10(1) pg10377 PubMed Id 32587357 First Author Alenazi, Y Title Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets. Citation Scientific Reports; 8(1) pg6333 PubMed Id 29679010
