Chemokines

Recombinant Human I-309 (CCL1)

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Product Details

Catalogue Number: 300-37
Description:
Recombinant Human I-309 (CCL1)

I-309 is a CC chemokine that signals through the CCR8 receptor.  It is secreted by T-lymphocytes, monocytes and mast cells.  I-309 chemoattracts monocytes and Th2 differentiated T-cells, but not neutrophils.  Human I-309 is active on murine cells.  Recombinant Human I-309 is an 8.5 kDa protein consisting of 74 amino acid residues that include six cysteine residues, of which four are the highly conserved cysteine residues present in CC chemokines.  Unlike some CC chemokines, whose biologically active form in solution is a non-disulfide-linked dimer, the biologically active form of I-309 is monomeric.

Source: E.coli

Synonyms: CCL1, TCA-3

AA Sequence: SKSMQVPFSR CCFSFAEQEI PLRAILCYRN TSSICSNEGL IFKLKRGKEA CALDTVGWVQ RHRKMLRHCP SKRK

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human monocytes population using a concentration range of 10.0-30.0 ng/ml.

Calculated Molecular Weight: 8.5 kDa

Accession Number: P22362

Gene ID: 6346

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Barington, L
Title
Role of Conserved Disulfide Bridges and Aromatic Residues in Extracellular Loop 2 of Chemokine Receptor CCR8 for Chemokine and Small Molecule Binding.
Citation
The Journal of Biological Chemistry; 291(31) pg16208-20
PubMed Id
First Author
Yasuoka, H
Title
Increased both PD-L1 and PD-L2 expressions on monocytes of patients with hepatocellular carcinoma was associated with a poor prognosis
Citation
Scientific Reports; 10(1) pg10377
PubMed Id
First Author
Alenazi, Y
Title
Genetically engineered two-warhead evasins provide a method to achieve precision targeting of disease-relevant chemokine subsets.
Citation
Scientific Reports; 8(1) pg6333
PubMed Id