Recombinant Murine Noggin 3 ComentariosSubmit a Review Detalles del Producto Nùmero de Catalogo 250-38 Descripcion Noggin belongs to a group of diffusible proteins that bind to ligands of the TGF-β family, and regulate their activity by inhibiting their access to signaling receptors. Noggin was originally identified as a BMP-4 antagonist whose action was critical for proper formation of the head and other dorsal structures. Consequently, noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of noggin in mice results in prenatal death, and a recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant Murine Noggin is a 46.4 kDa disulfide-linked homodimer consisting of two 206 amino acid polypeptide chains. Source: E.coli Synonyms: None AA Sequence (monomer): MQHYLHIRPA PSDNLPLVDL IEHPDPIFDP KEKDLNETLL RSLLGGHYDP GFMATSPPED RPGGGGGPAG GAEDLAELDQ LLRQRPSGAM PSEIKGLEFS EGLAQGKKQR LSKKLRRKLQ MWLWSQTFCP VLYAWNDLGS RFWPRYVKVG SCFSKRSCSV PEGMVCKPSK SVHLTVLRWR CQRRGGQRCG WIPIQYPIIS ECKCSC Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to inhibit 5.0 ng/ml of BMP-4 induced alkaline phosphatase production by ATDC5 chondrogenic cells. The expected ED50 for this effect is 1.0-2.0 ng/ml of Noggin. Calculated Molecular Weight: 46.4 kDa Accession Number: P97466 Gene ID: 18121 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Human, Mouse References PubMed SDS Búsqueda del CoA Product Line Country Of Origin: USA Not for human use. Research Interest Organoids Bone, Skeletal, Cartilage Immune System Neurobiology Stem Cells & Differentiation product.subtitle.recentcitations Primer autor Fujimura, T Titulo Identifying a Lung Stem Cell Subpopulation by Combining Single-Cell Morphometrics, Organoid Culture, and Transcriptomics. Citar Stem cells (Dayton, Ohio); PudMed id 37468433 Primer autor Cambuli, F Titulo Intra-epithelial non-canonical Activin A signaling safeguards prostate progenitor quiescence. Citar EMBO reports; 23(5) pge54049 PudMed id 35253958 Primer autor Vougioukalaki, M Titulo Different responses to DNA damage determine ageing differences between organs. Citar Aging Cell; 21(4) pge13562 PudMed id 35246937 product.subtitle.productreviews Comentarios existentes organoids Works perfect with both human and murine pancreatic organoids. De: Mitesh | Fecha: 09/07/2020 × organoids Works perfect with both human and murine pancreatic organoids. De: Mitesh | Fecha: 09/07/2020 Close Murine Noggin for CRC and pan Organoid Culture Murine Noggin I am using for Human as well as mouse Pancreas, Colon and Rectal Organoid culture medias.Consistent activity each lot and next day delivery. De: Hardik | Fecha: 14/08/2020 × Murine Noggin for CRC and pan Organoid Culture Murine Noggin I am using for Human as well as mouse Pancreas, Colon and Rectal Organoid culture medias.Consistent activity each lot and next day delivery. De: Hardik | Fecha: 14/08/2020 Close mNoggin for organoids culture We have used it for both mouse and human pancreatic organoids and it works perfectly! De: Pilar | Fecha: 27/08/2020 × mNoggin for organoids culture We have used it for both mouse and human pancreatic organoids and it works perfectly! De: Pilar | Fecha: 27/08/2020 Close