Animal-Free Cytokines

Animal-Free Recombinant Human IL-2

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Product Details

Catalogue Number: AF-200-02
Description:

IL-2 is a powerful immunoregulatory lymphokine produced by T cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant Human IL-2 is a 15.5 kDa protein, containing 134 amino acid residues including one intrachain disulfide bond.

Manufactured using all Animal-Free reagents.

Source: E.coli

Synonyms: Interleukin-2, T-cell growth factor (TCGF), Aldesleukin

AA Sequence: MAPTSSSTKK TQLQLEHLLL DLQMILNGIN NYKNPKLTRM LTFKFYMPKK ATELKHLQCL EEELKPLEEV LNLAQSKNFH LRPRDLISNI NVIVLELKGS ETTFMCEYAD ETATIVEFLN RWITFAQSII STLT

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of murine CTLL-2 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.

This product has been tested against the WHO standard. International Unit information can be found here.

Calculated Molecular Weight: 15.5 kDa

Accession Number: P60568

Gene ID: 3558

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Sage, A P
Title
Assessment of long non-coding RNA expression reveals novel mediators of the lung tumour immune response
Citation
Scientific Reports; 10(1) pg16945
PubMed Id
First Author
De Giovanni, C
Title
Human responses against HER-2-positive cancer cells in human immune system-engrafted mice.
Citation
British Journal of Cancer; 107(8) pg1302-9
PubMed Id
First Author
Wun, K S
Title
Human and mouse type I natural killer T cell antigen receptors exhibit different fine specificities for CD1d-antigen complex.
Citation
The Journal of Biological Chemistry; 287(46) pg39139-48
PubMed Id