Animal-Free Recombinant Human IL-2 0 ReviewsSubmit a Review Product Details Catalogue Number: AF-200-02 Description: IL-2 is a powerful immunoregulatory lymphokine produced by T cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages and oligodendrocytes. Recombinant Human IL-2 is a 15.5 kDa protein, containing 134 amino acid residues including one intrachain disulfide bond. Manufactured using all Animal-Free reagents. Source: E.coli Synonyms: Interleukin-2, T-cell growth factor (TCGF), Aldesleukin AA Sequence: MAPTSSSTKK TQLQLEHLLL DLQMILNGIN NYKNPKLTRM LTFKFYMPKK ATELKHLQCL EEELKPLEEV LNLAQSKNFH LRPRDLISNI NVIVLELKGS ETTFMCEYAD ETATIVEFLN RWITFAQSII STLT Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: The ED50 was determined by the dose-dependent stimulation of the proliferation of murine CTLL-2 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg. This product has been tested against the WHO standard. International Unit information can be found here. Calculated Molecular Weight: 15.5 kDa Accession Number: P60568 Gene ID: 3558 crossreactivity: Cow + Mouse, Human, Mouse References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest CAR T Cell COVID-19 AIDS/HIV Cancer Cell Culture Diabetes/Weight Regulation Immune System Inflammation Neurobiology Stem Cells & Differentiation Wound Healing Allergy Transplantation product.subtitle.recentcitations First Author Sage, A P Title Assessment of long non-coding RNA expression reveals novel mediators of the lung tumour immune response Citation Scientific Reports; 10(1) pg16945 PubMed Id 33037279 First Author De Giovanni, C Title Human responses against HER-2-positive cancer cells in human immune system-engrafted mice. Citation British Journal of Cancer; 107(8) pg1302-9 PubMed Id 22929887 First Author Wun, K S Title Human and mouse type I natural killer T cell antigen receptors exhibit different fine specificities for CD1d-antigen complex. Citation The Journal of Biological Chemistry; 287(46) pg39139-48 PubMed Id 22995911
