I-TAC is a "non-ELR" CXC chemokine that is regulated by interferon and signals through the CXCR3 receptor. I-TAC is chemoattractant for IL-2-activated T cells, but does not affect freshly isolated un-stimulated T cells, neutrophils, or monocytes. Recombinant Murine I-TAC is a 9.0 kDa protein containing 79 amino acid residues, including the four highly conserved cysteine residues present in CXC chemokines.
Interferon Inducible T-Cell α Chemokine, CXCL11, B-R1
FLMFKQGRCL CIGPGMKAVK MAEIEKASVI YPSNGCDKVE VIVTMKAHKR QRCLDPRSKQ ARLIMQAIEK KNFLRRQNM
≥ 98% by SDS-PAGE gel and HPLC analyses.
Determined by its ability to chemoattract murine CXCR3-transfected HEK293 cells using a concentration range of 10.0-100.0 ng/ml.
Calculated Molecular Weight:
Not for human use.