Recombinant Murine JE/MCP-1 (CCL2) 0 ReviewsSubmit a Review Product Details Catalogue Number: 250-10 Description: The MCP proteins are members of the CC chemokine family that signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross-reacts across species. Recombinant Murine JE is a 13.8 kDa protein containing 125 amino acid residues, including the four highly conserved cysteine residues present in the CC chemokines. Source: E.coli Synonyms: Monocyte Chemotactic Protein-1, CCL2, MCAF, JE (murine) AA Sequence: QPDAVNAPLT CCYSFTSKMI PMSRLESYKR ITSSRCPKEA VVFVTKLKRE VCADPKKEWV QTYIKNLDRN QMRSEPTTLF KTASALRSSA PLNVKLTRKS EANASTTFST TTSSTSVGVT SVTVN Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract Balb/C mouse spleen MNCs using a concentration range of 1.0-20.0 ng/ml. Calculated Molecular Weight: 13.8 kDa Accession Number: P10148 Gene ID: 20296 crossreactivity: Bacteria, Human, Monkey, Mouse, Rabbit, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Angiogenesis/Cardiovascular Cancer Chemotaxis Immune System Inflammation Neurobiology Wound Healing Allergy product.subtitle.recentcitations First Author Namekata, K Title Roles of the DOCK-D family proteins in a mouse model of neuroinflammation. Citation The Journal of Biological Chemistry; 295(19) pg6710-6720 PubMed Id 32241915 First Author Núñez, V Title Retinoid X receptor alpha controls innate inflammatory responses through the up-regulation of chemokine expression. Citation Proceedings of the National Academy of Sciences of the United States of America; 107(23) pg10626-31 PubMed Id 20498053 First Author Tager, A M Title BLTR mediates leukotriene B(4)-induced chemotaxis and adhesion and plays a dominant role in eosinophil accumulation in a murine model of peritonitis. Citation The Journal of Experimental Medicine; 192(3) pg439-46 PubMed Id 10934232
