Recombinant Murine JE/MCP-1 (CCL2) 0 ReviewsSubmit a Review Product Details Catalogue Number: 250-10 Description: The MCP proteins are members of the CC chemokine family that signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated T cells, basophils, NK cells, and immature dendritic cells. The MCP family cross-reacts across species. Recombinant Murine JE is a 13.8 kDa protein containing 125 amino acid residues, including the four highly conserved cysteine residues present in the CC chemokines. Source: E.coli Synonyms: Monocyte Chemotactic Protein-1, CCL2, MCAF, JE (murine) AA Sequence: QPDAVNAPLT CCYSFTSKMI PMSRLESYKR ITSSRCPKEA VVFVTKLKRE VCADPKKEWV QTYIKNLDRN QMRSEPTTLF KTASALRSSA PLNVKLTRKS EANASTTFST TTSSTSVGVT SVTVN Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses. Biological Activity: Determined by its ability to chemoattract Balb/C mouse spleen MNCs using a concentration range of 1.0-20.0 ng/ml. Calculated Molecular Weight: 13.8 kDa Accession Number: P10148 Gene ID: 20296 Endotoxin: Endotoxin level is < 0.1 ng/ug of protein (< 1 EU/ug) crossreactivity: Bacteria, Human, Monkey, Mouse, Rabbit, Rat References PubMed SDS CoA Search Product Line Country Of Origin: USA Not for human use. Research Interest COVID-19 Angiogenesis/Cardiovascular Cancer Chemotaxis Immune System Inflammation Neurobiology Wound Healing Allergy product.subtitle.recentcitations First Author Wang, W Title Stromal induction of BRD4 phosphorylation Results in Chromatin Remodeling and BET inhibitor Resistance in Colorectal Cancer Citation Nature Communications; 12(1) pg4441 PubMed Id 34290255 First Author Zhang, Y Title MED1 Deficiency in Macrophages Accelerates Intimal Hyperplasia via ROS Generation and Inflammation. Citation Oxidative Medicine And Cellular Longevity; 2021 pg3010577 PubMed Id 34853629 First Author Jeong, Y H Title Mice Lacking the Purinergic Receptor P2X5 Exhibit Defective Inflammasome Activation and Early Susceptibility to Listeria monocytogenes. Citation Journal of immunology (Baltimore, Md. : 1950); 205(3) pg760-766 PubMed Id 32540996
