Chemokines

Recombinant Human MCP-4 (CCL13)

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Product Details

Catalogue Number: 300-24
Description:


Recombinant Human MCP-4 (CCL13)

The MCP proteins are members of the CC chemokine family that signal through CCR2 and, with the exception of MCP-1, other CCR receptors. The MCP proteins chemoattract and activate monocytes, activated Tcells, basophils, NK cells, and immature dendritic cells. The MCP family cross-reacts across species. Recombinant Human MCP-4 is an 8.6 kDa protein containing 75 amino acid residues including the four highly conserved cysteine residues present in the CC chemokines.

Source: E.coli

Synonyms: Monocyte Chemotactic Protein-4, CCL13, NCC-1

AA Sequence: QPDALNVPST CCFTFSSKKI SLQRLKSYVI TTSRCPQKAV IFRTKLGKEI CADPKEKWVQ NYMKHLGRKA HTLKT

Purity: ≥ 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity: Determined by its ability to chemoattract human monocytes using a concentration of 10.0-100.0 ng/ml.

Calculated Molecular Weight: 8.6 kDa

Accession Number: Q99616

crossreactivity:
Country Of Origin: USA

Not for human use.

Research Interest

product.subtitle.recentcitations

First Author
Tiffany, H L
Title
Identification of CCR8: a human monocyte and thymus receptor for the CC chemokine I-309.
Citation
The Journal of Experimental Medicine; 186(1) pg165-70
PubMed Id
First Author
Singh, K
Title
Yeast surface display identifies a family of evasins from ticks with novel polyvalent CC chemokine-binding activities.
Citation
Scientific Reports; 7(1) pg4267
PubMed Id
First Author
Sabroe, I
Title
A small molecule antagonist of chemokine receptors CCR1 and CCR3. Potent inhibition of eosinophil function and CCR3-mediated HIV-1 entry.
Citation
The Journal of Biological Chemistry; 275(34) pg25985-92
PubMed Id